The Advantages of Carvedilol in Coronary Artery Disease

Dilatrend (carvedilol) is a nonselective beta and alpha blocker with antioxidation and antiprolipherative effects. These effects prevent mechanical damage of the endothelium of coronary arteries and have no negative influence on metabolic risk factors: lipid prophyl and insulin resistence. With beta-blockade, dilatrend (carvedilol) reduces the heart rate and blood pressure, with alpha-blockade it reduces the peripheral vascular resistence and in that way decreases the myocardial oxygen consumption and myocardial wall stress. Dilatrend (carvedilol) prolonges exercise limits (duration of exercise). Applied in the acute phase of myocardial infarction, dilatrend (carvedilol) increases the patients' survival rate, reduces new coronary events, and with antioxydation action it prevents reperfusion arrhythmias. With positive hymodinamic effects it improves the left ventricle function in patients with ischemic cardiomyopathy, and gives a chance for survival to the coronary patients who run high surgery risk.